Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression A Randomized Clinical Trial: From JAMA Network Key Points Question Is intranasal esketamine hydrochloride an efficacious treatment option for patients with treatment-resistant depression? Findings In this randomized, double-blind clinical trial of 67 adults with treatment-resistant depression, significant improvement of depressive symptoms, […]